COVID-19 Neutralizing Antibody Rapid Detection Kit
What are Neutralizing Antibodies
Not all the antibodies are neutralizing. Non-neutralizing antibodies, or binding antibodies, are able to bind to viral antigens but do not block viral infection. Binding antibodies can flag the viral antigen to trigger immune responses but the presence of binding antibodies does not reflect the level of immunity. Neutralizing antibodies (NAbs) are antibodies that not only bind to viral antigens, but also block viral infection. The presence of NAb can be used to evaluate immunity status after infection or vaccination.
Neutralizing Antibody Rapid Test Intended Use
The 2019 novel coronavirus (SARS-CoV-2) has several structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N). The S-protein contains a receptor binding domain (RBD), which can recognize the cell surface receptor, angiotensin-converting enzyme-2 (ACE2). In a recent study, neutralizing antibody (NAb) can block the interaction between the receptor-binding domain (RBD) of the novel coronavirus spike protein with the ACE2 cell surface receptor. The level of NAb, therefore, can be used to analyze a patient’s immunity against future SARS-CoV-2 infection. This COVID-19 neutralizing antibody lateral flow assay rapidly detects any antibodies that can neutralize the RBD-ACE2 interaction.
Intended Use:
The kit is used for the SARS-CoV-2 neutralizing antibodies in the serum, plasma or whole blood of people who are suspected of being infected with pneumonia of the SARS-CoV-2 and those immunized with the SARS-CoV-2. The neutralizing antibody testing is generally used to test samples of people who have recovered from the novel coronaviruses infection and those who have been immunized with the SARS-CoV-2 vaccine..
Storage Conditions and Shelf Life:
Stored in a dry place at 2-30 ℃ and the shelf life is 18 months.
Detection Principle:
The kit adopts immunochromatography and the test card contains: 1) Colloidal gold-labeled SARS-CoV-2 RBD recombinant protein and antibody chicken IgY colloidal gold marker; 2) The T-line and a quality control line are fixedon the nitrocellulose membrane. The T-line is fixed with ACE2 protein and the quality control line is fixed with rabbit anti-chicken IgY antibody.
Sample Requirements:
The applicable sample types for this kit are serum, plasma and whole blood.
